![]() There are clear sexual dimorphisms in the epidemiology, pathophysiology and sequelae of obesity and its accompanying metabolic disorders, with females often better protected compared to males. Obesity is defined as the excessive accumulation of body fat and is associated with an increased risk of developing major health problems such as cardiovascular disease, diabetes and stroke. Thus, Zn supplementation may not be sufficient to protect from obesity-related dysfunctions. However, an increase in acetate levels was observed, which suggests a partial beneficial effect of Zn. Our findings showed that Zn could not protect obese animals from intestinal dysbiosis. In addition, synaptophysin was decreased in the hippocampus, which may affect synaptic function. BBB may also be compromised in CAF-fed animals, as claudin-5 expression is reduced in the cerebral cortex. ![]() Obese rats showed dysbiosis, morphological changes, short-chain fatty acid (SCFA) reduction, and increased saturated fatty acids in the colon. At the end of the experiment, we evaluated the colon morphology, composition of gut microbiota, intestinal fatty acids, integrity of the intestinal barrier and blood–brain barrier (BBB), and neuroplasticity markers in the cerebral cortex and hippocampus. From week 16, Zn supplementation was started (10 mg/kg/day). Rats were fed a cafeteria diet (CAF), composed of ultra-processed and highly caloric and palatable foods, for 20 weeks to induce obesity. The present study aimed to evaluate the effect of Zn supplementation on the intestinal microbiota, fatty acid profile, and neurofunctional parameters in obese male Wistar rats. Zinc (Zn) plays an important role in metabolic homeostasis and may modulate neurological impairment related to obesity. Thus, our data shows the existence of a link between gut Akkermansia muciniphila abundance and adipose tissue homeostasis on the onset of obesity, thus reinforcing the beneficial role of this bacterium on metabolism. Different approaches, including multifactorial analysis, showed that these changes in Akkermansia muciniphila were robustly correlated with the expression of lipid metabolism and inflammation markers in adipose tissue, as well as several circulating parameters (i.e., glucose, insulin, triglycerides, leptin) from DIO mice. ![]() We found that Akkermansia muciniphila abundance was strongly and negatively affected by age and HFD feeding and to a lower extend Bilophila wadsworthia was the only taxa following an opposite trend. In this report, we studied the consequences of high-fat diet (HFD) administration on metabolic parameters and gut microbiota composition over different periods of time. In the context of obesity, enhanced adiposity is accompanied by low-grade inflammation of this tissue but the exact link with gut microbial community remains unknown. Indeed, diet-induced obesity (DIO) has been associated to substantial changes in gut microbiota composition in rodent models. Recent evidence indicates that the gut microbiota plays a key role in the pathophysiology of obesity. ![]()
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